The series shows the relationship between Luisita and Amelia, one of the most beloved couples of Amar es para siempre, in the year 2020: they do not know each other, they are young women of the millennial generation who have before them the freedoms and possibilities of the current society, although they also encounter the stumbling blocks that still remain. In addition to the love story of its protagonists, #Luimelia deals with topics such as LGTBQ visibility, feminism or interaction on social networks.