Chema tells the story of how Chema Venegas (Mauricio Ochmann) started in organized crime and rose through the ranks to become the head of the cartel that he leads in the series The Lord of the Skies. Chema began breaking the law at a young age, transporting marijuana across the US-Mexico border when he was a child, gradually experiencing his path to becoming a successful and skilled leader, earning his place through bloodshed and brutality, in the history of drug trafficking. Since he was a young man, El Chema has been one of the most important public enemies of both the governments of the United States and Mexico.